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The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma
Department of Biology, Jacksonville State University, Jacksonville, AL 36265, USA
* Corresponding Author: LE SU. Email:
Oncology Research 2025, 33(5), 1001-1005. https://doi.org/10.32604/or.2025.060573
Received 05 November 2024; Accepted 03 January 2025; Issue published 18 April 2025
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Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX. The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma, and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma, but emerging evidence suggests that upon depletion of SS18-SSX, an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival. In this article, we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of synovial sarcoma cells to SS18-SSX targeted therapeutics.Graphic Abstract
Keywords
SS18-SSX; Synovial sarcoma; Targeted therapy
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APA Style
ANCHONDO, G.M., PARKER, K., BRUCE, A., CORTEZ, E., SU, L. (2025). The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma. Oncology Research, 33(5), 1001–1005. https://doi.org/10.32604/or.2025.060573
Vancouver Style
ANCHONDO GM, PARKER K, BRUCE A, CORTEZ E, SU L. The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma. Oncol Res. 2025;33(5):1001–1005. https://doi.org/10.32604/or.2025.060573
IEEE Style
G. M. ANCHONDO, K. PARKER, A. BRUCE, E. CORTEZ, and L. SU, “The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma,” Oncol. Res., vol. 33, no. 5, pp. 1001–1005, 2025. https://doi.org/10.32604/or.2025.060573
Copyright © 2025 The Author(s). Published by Tech Science Press.This work is licensed under a Creative Commons Attribution 4.0 International License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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