Open Access

REVIEW

Mechanistic Insights into N-Oleoylethanolamide-Mediated Hepatoprotection via PPAR-α

Darya Ivashkevich, Arina Ponomarenko^*, Igor Manzhulo, Inessa Dyuizen

A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, 119334, Russia

* Corresponding Author: Arina Ponomarenko. Email:

BIOCELL 2025, 49(4), 607-627. https://doi.org/10.32604/biocell.2025.061606

Received 28 November 2024; Accepted 08 February 2025; Issue published 30 April 2025

Abstract

The high prevalence of obesity and associated nonalcoholic fatty liver disease (NAFLD) in the population determines the increased interest in identifying molecular targets for regulating the processes underlying these pathologies. The search for new endogenous bioregulators of lipid metabolism and their inclusion in therapeutic regimens for the treatment of patients is becoming a potentially promising direction in science and medicine. Oleoylethanolamide (OEA) is an endogenous lipid mediator capable of exerting multiple hypolipidemic, anti-inflammatory, and hepatoprotective effects mediated by agonism with receptors of the peroxisome proliferator-activated receptor (PPAR) family (PPAR-α and PPAR-γ). This review focuses on a detailed description of the PPAR-dependent mechanisms of the hepatoprotective activity of OEA in the development of NAFLD. The main attention is paid to such topics as reduction of oxidative stress and inflammation, inhibition of liver fibrogenesis, suppression of hepatocyte death, and changes in various parameters of lipid metabolism.

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Keywords

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