A Tense Race: Correlation of Liver Stiffness with Ultrasound Elastography and Hemodynamics in Fontan Patients
Yuen Lo Yau, Matthew S. Purlee, Lindsey M. Brinkley, Dipankar Gupta, David M. Saulino, Dalia Lopez-Colon, John-Anthony Coppola, Dhanashree Rajderkar, Himesh Vyas
Congenital Heart Disease, Vol.20, No.2, pp. 265-272, 2025, DOI:10.32604/chd.2025.065661
（This article belongs to the Special Issue:
Novel Insights into Congenital Heart Disease: Pathophysiology, Biomarkers, and Future Directions)
Abstract Background: Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE.
Methods: A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and…
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